반응 #1807521

반응 방정식

triethylamine

triphenylchloromethane

3-bromo-2-[2'-(1H-tetrazol-5-yl)-phenyl]-5-methylbenzofuran

→

3-bromo-2-[2'-(1-trityltetrazol-5-yl)-phenyl]-5-methylbenzofuran

용매

CH2Cl2

반응 조건

후처리

1. 1
   세척The reaction solution is washed with 150 ml of water and 150 ml of brine
2. 2
   농축concentrated in vacuo to a volume of 50 ml
3. 3
   기타chromatographed on silica gel 60 (40-63 μm)

실험 절차

5.89 g of triethylamine, 8.14 g of triphenylchloromethane and 0.10 g of 4-N,N-dimethylaminopyridine are added in succession to a suspension of 10.37 g of 3-bromo-2-[2'-(1H-tetrazol-5-yl)-phenyl]-5-methylbenzofuran in 300 ml of CH2Cl2 and the batch is stirred for 3 hours at room temperature. The reaction solution is washed with 150 ml of water and 150 ml of brine, concentrated in vacuo to a volume of 50 ml and chromatographed on silica gel 60 (40-63 μm) using CH2Cl2 as eluant. The product, of Rf =0.82 (CH2Cl2 /CH3OH (95:5) ), yields crystalline 3-bromo-2-[2'-(1-trityltetrazol-5-yl)-phenyl]-5-methylbenzofuran, m.p. 199°-200°, from ether.

출처