반응 #1806790

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L-rhamnose

5-deoxy-L-arabinose-phenylhydrazone

2,4,5-triamino-6-hydroxy-pyrimidine

→

hydrazine

tetrahydro-L-biopterin

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실험 절차

1',2'-diacyl-L-biopterin of the general formula (III) can be prepared by converting L-rhamnose to an acyl derivative of 5-deoxy-L-arabinose-phenylhydrazone through a 1,1-dialkylsulfonyl-L-rhamnose, reacting the obtained acyl derivative with 2,4,5-triamino-6-hydroxy-pyrimidine to obtain a hydrazine derivative of tetrahydro-L-biopterin and oxidizing the hydrazine derivative, without isolating the intermediate products in the course of reaction from the 1,1-dialkylsufonyl-L-rhamnose to the 1',2'-diacyl-L-biopterin.

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