반응 #1797493

반응 방정식

5-aminoindane

acetic anhydride

→

5-(N-acetylamino)indane

수율 84.6%

용매

—

ice water

acetic acid

반응 조건

후처리

1. 1
   workup.ADDITIONAfter completion of the dropwise addition
2. 2
   기타After completion of the reaction
3. 3
   기타the reaction liquid
4. 4
   workup.STIRRINGwhile stirring
5. 5
   기타Crystals precipitated
6. 6
   여과were filtered off
7. 7
   세척washed with 1,000 ml of water
8. 8
   기타The crystals obtained
9. 9
   기타were dried

실험 절차

33.3 g (0.25 mol) of 5-aminoindane (a product of Tokyo Chemical Industry Co. Ltd.) was dissolved in 250 ml of glacial acetic acid, the resulting solution was heated to 50° C., and 51.0 g (0.5 mol) of acetic anhydride was added dropwise thereto. After completion of the dropwise addition, the resulting solution was stirred for 4 hours. After completion of the reaction, the reaction liquid was poured in 1,500 ml of ice water while stirring. Crystals precipitated were filtered off, and washed with 1,000 ml of water. The crystals obtained were dried to obtain 37.06 g of 5-(N-acetylamino)indane (yield: 84.6%, melting point: 100.5 to 103.5° C.)

출처