반응 #1791

반응 방정식

methyl 4-[N-Boc-cis-1-amino-4-cyclohexanoyloxy]-2-methoxybenzoate

H2O

LiOH.H2O

→

4-[N-Boc-cis-1-amino-4-cyclohexanoyloxy]-2-methoxybenzoic acid

용매

THF

반응 조건

후처리

1. 1
   온도cooled to ambient temperature
2. 2
   기타The solvent was removed under reduced pressure
3. 3
   세척CH2Cl2 and eluted with same
4. 4
   기타The solvent was removed under reduced pressure

실험 절차

To a stirred solution of methyl 4-[N-Boc-cis-1-amino-4-cyclohexanoyloxy]-2-methoxybenzoate (220 mg, 0.52 mmol) in THF:H2O (5 mL: 1 mL) was added LiOH.H2O (67.6 mg, 1.59 mmol). The reaction was heated to 45° C. over 12 h and then cooled to ambient temperature. The solvent was removed under reduced pressure. The crude solid passed through a plug of silca gel packed in 50:50 MeOH:CH2Cl2 and eluted with same. The solvent was removed under reduced pressure to afford 4-[N-Boc-cis-1-amino-4-cyclohexanoyloxy]-2-methoxybenzoic acid as a white solid.

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