반응 #1790494

반응 방정식

Methyl 1-methyl-5-benzoylpyrrole-2-carboxylate

sodium hydroxide

→

1-Methyl-5-benzoylpyrrole-2-carboxylic Acid

용매

methanol

반응 조건

후처리

1. 1
   추출extracted with ether
2. 2
   여과recovered by filtration (0.47 g., m.p. 178°-181° C.)
3. 3
   기타Recrystallization from acetone/hexane afforded product for analysis (0.34 g., m.p. 178°-180° C.)

실험 절차

Methyl 1-methyl-5-benzoylpyrrole-2-carboxylate (0.78 g.) was heated on a steam bath for 1 hour with 40 ml. of 1 N sodium hydroxide and 20 ml. of methanol. The reaction mixture was cooled to room temperature, extracted with ether, made acid with conc. hydrochloric acid and 1-methyl-5-benzoylpyrrole-2-carboxylic acid recovered by filtration (0.47 g., m.p. 178°-181° C.). Recrystallization from acetone/hexane afforded product for analysis (0.34 g., m.p. 178°-180° C.).

출처