반응 #1787925

반응 방정식

hydrochloric acid

7-(2-chlorophenyl)-4-methyl-5,6,7,8-tetrahydrocinnolin-5-one

1-amino-3-hydroxyguanidine hydrochloride

→

7-(2-chlorophenyl)-5-(1-hydroxyguanidin-3-yl)imino-4-methyl-5,6,7,8-tetrahydrocinnoline hydrochloride

수율 155.8%

용매

ethanol

반응 조건

후처리

1. 1
   농축The reaction solution was concentrated under reduced pressure
2. 2
   세척the residue was washed with ethanol
3. 3
   기타dried

실험 절차

To a mixture of 7-(2-chlorophenyl)-4-methyl-5,6,7,8-tetrahydrocinnolin-5-one (101 mg) and 1-amino-3-hydroxyguanidine hydrochloride (48 mg) were added ethanol (2 ml) and concentrated hydrochloric acid (0.05 ml), and the mixture was stirred at 90° C. for 1.5 hours. The reaction solution was concentrated under reduced pressure, and the residue was washed with ethanol and dried to give 7-(2-chlorophenyl)-5-(1-hydroxyguanidin-3-yl)imino-4-methyl-5,6,7,8-tetrahydrocinnoline hydrochloride (Compound 156) (110 mg) as gray white crystals.

출처