반응 #1787854

반응 방정식

hydrochloric acid

7-(2-chlorophenyl)-4-methyl-5,6,7,8-tetrahydrocinnolin-5-one

aminoguanidine hydrochloride

→

7-(2-chlorophenyl)-5-guanidinoimino-4-methyl-5,6,7,8-tetrahydrocinnoline hydrochloride

수율 174.7%

용매

ethanol

반응 조건

후처리

1. 1
   온도the mixture was refluxed for 1.5 hours
2. 2
   온도cooled
3. 3
   기타Precipitated crystals
4. 4
   여과were filtered
5. 5
   세척washed with ethanol
6. 6
   기타dried

실험 절차

To a mixture of 7-(2-chlorophenyl)-4-methyl-5,6,7,8-tetrahydrocinnolin-5-one (0.218 g) and aminoguanidine hydrochloride (94 mg) were added ethanol (5 ml) and concentrated hydrochloric acid (0.1 ml), and the mixture was refluxed for 1.5 hours and cooled. Precipitated crystals were filtered, washed with ethanol and dried to give 7-(2-chlorophenyl)-5-guanidinoimino-4-methyl-5,6,7,8-tetrahydrocinnoline hydrochloride (Compound 129) (0.255 g) as crystals.

출처