반응 #1787791

반응 방정식

4-methyl-7-(2-methylphenyl)-5-oxo-cyclopenta[2,1-b]pyridine

aminoguanidine hydrochloride

hydrochloric acid

→

5-guanidinoimino-4-methyl-7-(2-methylphenyl)cyclopenta[2,1-b]pyridine hydrochloride

수율 71.8%

용매

ethanol

반응 조건

후처리

1. 1
   온도was refluxed for 2 hours
2. 2
   온도The reaction solution was cooled
3. 3
   기타precipitated crystals
4. 4
   여과were filtered
5. 5
   세척washed with ethanol
6. 6
   기타dried

실험 절차

A mixture of 4-methyl-7-(2-methylphenyl)-5-oxo-cyclopenta[2,1-b]pyridine (48 mg), aminoguanidine hydrochloride (25 mg) and concentrated hydrochloric acid (40 mg) in ethanol (1 ml) was refluxed for 2 hours. The reaction solution was cooled, and precipitated crystals were filtered, washed with ethanol and dried to give 5-guanidinoimino-4-methyl-7-(2-methylphenyl)cyclopenta[2,1-b]pyridine hydrochloride (Compound 91) (48 mg) as yellow crystals.

출처