반응 #1787766

반응 방정식

(±)-7-(2-chlorophenyl)-5-guanidinoimino-4-methyl-5,6,7,8-tetrahydroquinoline hydrochloride

sodium methoxide

→

(±)-7-(2-chlorophenyl)-5-guanidinoimino-4-methyl-5,6,7,8-tetrahydroquinoline

수율 98.0%

용매

methanol

methanol

반응 조건

후처리

1. 1
   기타Under reduced pressure, the solvent was evaporated
2. 2
   workup.ADDITIONto the residue was added water
3. 3
   여과The crystals were filtered
4. 4
   세척washed with water
5. 5
   기타dried

실험 절차

In methanol (1200 ml) was suspended (±)-7-(2-chlorophenyl)-5-guanidinoimino-4-methyl-5,6,7,8-tetrahydroquinoline hydrochloride (123.9 g), and to the suspension was added dropwise 28% sodium methoxide in methanol (119.2 ml). The mixture was stirred at 50° C. for 30 minutes. Under reduced pressure, the solvent was evaporated, and to the residue was added water. The crystals were filtered, washed with water and dried to give colorless crystals of (±)-7-(2-chlorophenyl)-5-guanidinoimino-4-methyl-5,6,7,8-tetrahydroquinoline (109.3 g).

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