반응 #1787763

반응 방정식

7-(2-chlorophenyl)-4-methyl-5,6,7,8-tetrahydroquinolin-5-one

aminoguanidine hydrochloride

hydrochloric acid

water

→

7-(2-chlorophenyl)-5-guanidinoimino-4-methyl-5,6,7,8-tetrahydroquinoline hydrochloride

수율 156.7%

용매

ethanol

반응 조건

후처리

1. 1
   온도was refluxed for 6 hours
2. 2
   기타Under reduced pressure, the solvent was evaporated
3. 3
   workup.DISSOLUTIONthe residue was dissolved in water
4. 4
   세척The mixture was washed with ethyl acetate
5. 5
   농축concentrated under reduced pressure
6. 6
   기타The residue was recrystallized from ethyl acetate-ethanol

실험 절차

A mixture of 7-(2-chlorophenyl)-4-methyl-5,6,7,8-tetrahydroquinolin-5-one (0.20 g), aminoguanidine hydrochloride (0.085 g), concentrated hydrochloric acid (0.11 ml), water (0.11 ml) and ethanol (20 ml) was refluxed for 6 hours. Under reduced pressure, the solvent was evaporated, and the residue was dissolved in water. The mixture was washed with ethyl acetate and concentrated under reduced pressure. The residue was recrystallized from ethyl acetate-ethanol to give 7-(2-chlorophenyl)-5-guanidinoimino-4-methyl-5,6,7,8-tetrahydroquinoline hydrochloride (Compound 61) (0.21 g) as colorless crystals.

출처