반응 #1786012

ord-f655ce69f62b49659adbbdec150516d0

반응 방정식

CC(C)(CC(=O)C(=O)Nc1ccc2c(c1Br)COC2=O)c1ccccc1
4-bromo-5-(4-methyl-2-oxo-4-phenyl-valeroylamino)-phthalide
Nc1ccc2c(c1)COC2=O
5-aminophthalide
C=CC(C)(C)CC(=O)C(=O)O
4,4-dimethyl-2-oxo-5-hexenoic acid
→
C=CC(C)(C)CC(=O)C(=O)Nc1ccc2c(c1)C(=O)OC2
6-(4,4-Dimethyl-2-oxo-5-hexenoylamino)-phthalide

반응물

CC(C)(CC(=O)C(=O)Nc1ccc2c(c1Br)COC2=O)c1ccccc1
4-bromo-5-(4-methyl-2-oxo-4-phenyl-valeroylamino)-phthalide
Nc1ccc2c(c1)COC2=O
5-aminophthalide
C=CC(C)(C)CC(=O)C(=O)O
4,4-dimethyl-2-oxo-5-hexenoic acid

시약

없음

반응 조건

상세 조건
See reaction.notes.procedure_details.

후처리

  1. 1
    기타was obtained analogously to the process that

실험 절차

was obtained analogously to the process that is described for 4-bromo-5-(4-methyl-2-oxo-4-phenyl-valeroylamino)-phthalide from 5-aminophthalide and 4,4-dimethyl-2-oxo-5-hexenoic acid, melting point 103-104° C.

출처

DOI: 10.6084/m9.figshare.5104873.v1특허: US06344454B1uspto-grants-2002_02