반응 #1785769

반응 방정식

4-bromo-7-(1-ethylpropyl)-1-methyl-1,3-dihydro-2H-benzimidazol-2-one

copper cyanide

→

title compound

수율 86.0%

7-(1-Ethylpropyl)-1-methyl-2-oxo-2,3-dihydro-1H-benzimidazole-4-carbonitrile

수율 86.0%

용매

sodium bicarbonate

1-methyl-2-pyrrolidone

반응 조건

후처리

1. 1
   기타was irradiated by microwave (200 w) at 150° C. for 1 h
2. 2
   온도After cooling, to the reaction mixture
3. 3
   추출extracted with ethyl acetate
4. 4
   건조The extract was dried over magnesium sulfate
5. 5
   여과filtered
6. 6
   농축concentrated in vacuo
7. 7
   세척The residue was washed with 50% diisopropyl ether/n-hexane

실험 절차

A mixture of 4-bromo-7-(1-ethylpropyl)-1-methyl-1,3-dihydro-2H-benzimidazol-2-one (300 mg, 1.01 mmol) and copper cyanide (116 mg, 1.30 mmol) in 1-methyl-2-pyrrolidone (3 mL) was irradiated by microwave (200 w) at 150° C. for 1 h. After cooling, to the reaction mixture was diluted with saturated sodium bicarbonate, and extracted with ethyl acetate. The extract was dried over magnesium sulfate, filtered, and concentrated in vacuo. The residue was washed with 50% diisopropyl ether/n-hexane to give the title compound (209 mg, 86%).

출처