반응 #1781647

ord-13ab2f395c4b48b1a05a2e4701b5f13b

반응 방정식

COC(=O)c1sc(C2=CCCCC2)cc1N(c1ccccc1)C(=O)[C@H]1CC[C@H](C)CC1
product
COC(=O)c1sc(C2=CCCCC2)cc1N(c1ccccc1)C(=O)[C@H]1CC[C@H](C)CC1
5-cyclohex-1-enyl-3-[(trans-4-methyl-cyclohexanecarbonyl)-phenyl-amino]-thiophene-2-carboxylic acid methyl ester
[Li+].[OH-]
lithium hydroxide
→
C[C@H]1CC[C@H](C(=O)N(c2ccccc2)c2cc(C3=CCCCC3)sc2C(=O)O)CC1
5-cyclohex-1-enyl-3-[(trans-4-methyl-cyclohexanecarbonyl)-phenyl-amino]-thiophene-2-carboxylic acid
수율 89.0%

반응물

COC(=O)c1sc(C2=CCCCC2)cc1N(c1ccccc1)C(=O)[C@H]1CC[C@H](C)CC1
product
COC(=O)c1sc(C2=CCCCC2)cc1N(c1ccccc1)C(=O)[C@H]1CC[C@H](C)CC1
5-cyclohex-1-enyl-3-[(trans-4-methyl-cyclohexanecarbonyl)-phenyl-amino]-thiophene-2-carboxylic acid methyl ester
[Li+].[OH-]
lithium hydroxide

시약

없음

반응 조건

상세 조건
See reaction.notes.procedure_details.

실험 절차

The product from Step II (38 mg, 0.09 mmol) was hydrolysed with lithium hydroxide as previously described (example 3, step VIII) to give 32 mg (89%) of 5-cyclohex-1-enyl-3-[(trans-4-methyl-cyclohexanecarbonyl)-phenyl-amino]-thiophene-2-carboxylic acid.

출처

DOI: 10.6084/m9.figshare.5104873.v1특허: US08158675B2uspto-grants-2012_04