반응 #1781

반응 방정식

2-ethyl nicotinic acid lithium salt

lithium aluminum hydride

→

2-ethyl-3 -hydroxymethylpyridine

용매

THF

반응 조건

후처리

1. 1
   온도then cooled to 0° C.
2. 2
   기타quenched with EtOAc (949 μL)
3. 3
   여과The solution was filtered
4. 4
   기타the solvent removed under reduced pressure
5. 5
   workup.ADDITIONToluene was added
6. 6
   기타the solvent was removed under reduced pressure

실험 절차

The 2-ethyl nicotinic acid lithium salt (5 g, 3.18 mmol) in distilled THF (400 mL) under nitrogen was cooled to 0° C. and lithium aluminum hydride (1M in THF) (25 mL) was added dropwise. The reaction was stirred for 3 hours at room temperature then cooled to 0° C. and quenched with EtOAc (949 μL), then H2O (949 μL), then 15% NaOH (949 μL), followed by H2O (2.8 mL). The solution was filtered and the solvent removed under reduced pressure. Toluene was added and the solvent was removed under reduced pressure to give the desired 2-ethyl-3 -hydroxymethylpyridine.

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