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3-chloro-2-fluoroaniline

N-[3-(5-Oxo-5,6,7,8-tetrahydro-naphthalen-2-yl)-phenyl]-methanesulfonamide

(4′-Fluoro-3′-methyl-biphenyl-3-yl)-hydrazine hydrochloride

3-methyl-4-fluorophenylboronic acid

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title material

N-{3-[10-Fluoro-9-(4-fluoro-3-methyl-phenyl)-5,11-dihydro-6H-benzo[a]carbazol-3-yl]-phenyl}-methanesulfonamide

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후처리

1. 1
   기타prepared as in example 70, steps 1 and 2
2. 2
   기타except that purification

실험 절차

The title material is prepared by reacting N-[3-(5-Oxo-5,6,7,8-tetrahydro-naphthalen-2-yl)-phenyl]-methanesulfonamide and (4′-Fluoro-3′-methyl-biphenyl-3-yl)-hydrazine hydrochloride (prepared as in example 70, steps 1 and 2 except using 3-methyl-4-fluorophenylboronic acid and 3-chloro-2-fluoroaniline as the coupling partners) in an analogous manner to example 1, step 3 except that purification is accomplished by reverse phase UV triggered HPLC: 1H NMR (400 MHz, d6-DMSO) δ 12.66 (s, 1H), 9.88 (s, 1H), 8.82 (d, J=8.7 Hz, 1H), 8.31 (m, 1H), 8.29 (d, J=8.6 Hz, 1H), 8.08 (d, J=8.2 Hz, 1H), 7.94 (m, 1H), 7.80 (d, J=8.6 Hz, 1H), 7.66 (m, 1H), 7.61 (m, 2H), 7.48 (m, 1H), 7.30 (m, 2H), 3.09 (m, 2H), 3.04 (s, 3H), 2.97 (m, 2H), 2.08 (s, 3H); LC/MS calculated for [M+H]+ C30H25F2N2O2S: 515.6, found: 515.0.

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