반응 #1772

반응 방정식

methyl 4-(1-indanoyloxy)-2-methoxy-benzoate

H2O

LiOH.H2O

→

4-(1-indanoyloxy)-2-methoxy-benzoic acid

용매

THF

반응 조건

후처리

1. 1
   온도cooled to ambient temperature
2. 2
   기타The solvent was removed under reduced pressure
3. 3
   세척EtOAc and eluted with 50:50 hexanes
4. 4
   기타The solvent was removed under reduced pressure

실험 절차

To a stirred solution of methyl 4-(1-indanoyloxy)-2-methoxy-benzoate (125 mg, 0.43 mmol) in THF:H2O (1 mL: 0.2 mL) was added LiOH.H2O (35.2 mg, 0.84 mmol). The reaction was heated to 45° C. over 12 h and then cooled to ambient temperature. The solvent was removed under reduced pressure. The crude solid was passed through a small plug of silca gel packed in 80:20 hexanes:EtOAc and eluted with 50:50 hexanes:EtOAc. The solvent was removed under reduced pressure to afford 4-(1-indanoyloxy)-2-methoxy-benzoic acid as a foam.

출처