반응 #1771991
ord-696188d0a22a43afa651f35351c4c027
반응 방정식
Boc-Pro(4,4-diMe)-OH
thionylchloride
methanol
→
4,4-Dimethylproline Methylester Hydrochloride Salt
반응 조건
상세 조건
See reaction.notes.procedure_details.
후처리
- 1농축The reaction mixture was concentrated to an amorphous solid (377 mg, 95%)
실험 절차
To a solution of Boc-Pro(4,4-diMe)-OH (0.5 g, 2.06 mmol) in anhydrous methanol (8 ml) was added dropwise thionylchloride (448 g, 6.18 mmol) and the reaction was stirred for six hours at room temperature. The reaction mixture was concentrated to an amorphous solid (377 mg, 95%).