반응 #1769054

반응 방정식

2-propanol

1,4,5,6-Tetrahydropyrimidine-5-carboxylic acid hydrochloride

thionyl chloride

charcoal

→

crystals

수율 84.0%

Isopropyl 1,4,5,6-Tetrahydropyrimidine-5-carboxylate Hydrochloride

수율 84.0%

반응 조건

후처리

1. 1
   온도The resulting mixture was refluxed 24 h
2. 2
   기타by evaporating unreacted alcohol

실험 절차

1,4,5,6-Tetrahydropyrimidine-5-carboxylic acid hydrochloride (1.0 g, 6.08 mmol) was suspended in 2-propanol (50 ml) and thionyl chloride (0.76 g, 6.39 mmol) was added dropwise. The resulting mixture was refluxed 24 h. The pink solution was treated with charcoal and then reduced in volume to 15 ml by evaporating unreacted alcohol. By allowing the solution to stand overnight, white crystals (1.08 g, 84%) were obtained in three crops, mp 170° C. 300 MHz nmr confirmed product. Microanalysis calc.: C 46.49, H 7.26, N 13.56, found: C 46.49, H 7.25, N 13.64.

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