반응 #1764231

반응 방정식

Sulfuric acid

tert-butyl 4-oxo-3-(2-oxo-1,2-dihydropyridin-3-yl)piperidine-1-carboxylate

→

1,5,6,7,8,9a-Hexahydro-furo[2,3-b:4,5-c′]dipyridine

용매

Acetonitrile

potassium carbonate

반응 조건

후처리

1. 1
   온도The reaction was heated at 60° C. until reaction complete by LCMS
2. 2
   workup.ADDITIONwas added cautiously to neutral pH (Effervescence)
3. 3
   여과the slurry was filtered
4. 4
   기타the filtrate evaporated
5. 5
   기타the resulting residue was used without further purification

실험 절차

Concentrated Sulfuric acid (1.0 mL, 18.8 mmol) was added to tert-butyl 4-oxo-3-(2-oxo-1,2-dihydropyridin-3-yl)piperidine-1-carboxylate (350 mg, 1.20 mmol). The resulting thick solution was stirred at room temperature overnight. The reaction was heated at 60° C. until reaction complete by LCMS. The reaction was diluted with 90% Acetonitrile 10% Water and solid potassium carbonate was added cautiously to neutral pH (Effervescence), the slurry was filtered and the filtrate evaporated, the resulting residue was used without further purification.

출처