반응 #1755509

반응 방정식

3-(β-D-glucopyranosyloxy)-4-[(4-iso-propoxyphenyl)methyl]-5-methyl-1H-pyrazole

N-(benzyloxycarbonyloxy)-succinimide

→

1-(benzyloxycarbonyl)-3-(β-D-glucopyranosyloxy)-4-[(4-isopropoxyphenyl)methyl]-5-methylpyrazole

수율 75.3%

용매

tetrahydrofuran

반응 조건

후처리

1. 1
   온도the mixture was heated
2. 2
   온도under reflux overnight
3. 3
   농축The reaction mixture was concentrated under reduced pressure
4. 4
   기타the residue was purified by column chromatography on silica gel (eluent: dichloromethane/methanol=10/1)

실험 절차

To a solution of 3-(β-D-glucopyranosyloxy)-4-[(4-iso-propoxyphenyl)methyl]-5-methyl-1H-pyrazole (1.3 g) in tetrahydrofuran (30 mL) was added N-(benzyloxycarbonyloxy)-succinimide (1.6 g), and the mixture was heated under reflux overnight. The reaction mixture was concentrated under reduced pressure, and the residue was purified by column chromatography on silica gel (eluent: dichloromethane/methanol=10/1) to give 1-(benzyloxycarbonyl)-3-(β-D-glucopyranosyloxy)-4-[(4-isopropoxyphenyl)methyl]-5-methylpyrazole (1.3 g).

출처