반응 #1755463

반응 방정식

1-[2-(3,5-dimethyl-phenyl)-1-thiophen-2-yl-ethyl]-3-(2-hydroxy-ethyl)-thiourea

1-[2-(3,5-Dimethyl-phenyl)-1-thien-2-yl-ethyl]-3-(2-hydroxy-ethyl)-thiourea

diisopropyethylamine

cyanomethyl-trimethyl-phosphonium iodide

→

title compound

수율 95.0%

(4,5-Dihydro-thiazol-2-yl)-[2-(3,5-dimethyl-phenyl)-1-thien-2-yl-ethyl]-amine

수율 95.0%

용매

propionitrile

반응 조건

후처리

1. 1
   추출Extraction with ethyl acetate
2. 2
   세척washing with potassium carbonate solution and water
3. 3
   기타by drying
4. 4
   기타evaporation of the solvent

실험 절차

To a solution of 1-[2-(3,5-dimethyl-phenyl)-1-thiophen-2-yl-ethyl]-3-(2-hydroxy-ethyl)-thiourea (0.30 g) from example 6 and diisopropyethylamine (0.16 g) in propionitrile (10 ml) was added cyanomethyl-trimethyl-phosphonium iodide (0.27 g, prepared according to Tetrahedron 2001, 57, 5451-54). The reaction mixture was heated up to 90° C. for 72 h. Extraction with ethyl acetate, washing with potassium carbonate solution and water followed by drying and evaporation of the solvent yielded 0.27 mg (95%) of the title compound as brownish oil.

출처