반응 #1755461

반응 방정식

2-methyl-propane-2-sulfinic acid [2-(3,5-dimethyl-phenyl)-1-(1-methyl-1H-pyrazol-4-yl)-ethyl]-amide

hydrogenchloride

→

2-(3,5-Dimethyl-phenyl)-1-(1-methyl-1H-pyrazol-4-yl)-ethylamine

수율 77.0%

용매

methanol

dioxane

반응 조건

후처리

1. 1
   기타The reaction mixture was quenched with aqueous potassium carbonate solution
2. 2
   추출extracted
3. 3
   건조the organic phases dried over magnesium sulfate
4. 4
   기타After evaporation of the solvent a yellowish oil
5. 5
   기타was obtained in 77% yield (1.05 g)

실험 절차

A solution of RS 2-methyl-propane-2-sulfinic acid [2-(3,5-dimethyl-phenyl)-1-(1-methyl-1H-pyrazol-4-yl)-ethyl]-amide (2.0 g) in methanol (12 ml) was treated with a solution of hydrogenchloride in dioxane (12 ml, 4 N) at room temperature overnight. The reaction mixture was quenched with aqueous potassium carbonate solution and adjusted to pH 8-9, extracted and the organic phases dried over magnesium sulfate. After evaporation of the solvent a yellowish oil was obtained in 77% yield (1.05 g).

출처