반응 #1755456

반응 방정식

imidazole

methyl 4-fluorobenzoate

potassium carbonate

→

1-(4′-methoxycarbonylphenyl)imidazole

수율 59.0%

용매

DMSO

반응 조건

후처리

1. 1
   온도After cooling to room temperature
2. 2
   여과Precipitated product is filtered off
3. 3
   세척washed with water

실험 절차

A mixture of imidazole (132 g, 1.9 mol), methyl 4-fluorobenzoate (170 ml, 1.3 mol) and potassium carbonate (357 g, 2.6 mol) in DMSO (200 ml) is stirred at 120° C. for 3 h. After cooling to room temperature, the mixture is added to ice-water. Precipitated product is filtered off and washed with water. Yield: 59%.

출처