반응 #1755

반응 방정식

water

trans-O-acetyl-4-(4-chloromethylphenyl)-cyclohexanol

potassium carbonate

diethylamine

→

trans-O-Acetyl-4-(4-diethylaminomethylphenyl)-cyclohexanol

용매

dimethylformamide

반응 조건

후처리

1. 1
   추출the mixture is extracted with methylene chloride
2. 2
   기타The organic phase is dried
3. 3
   기타evaporated down in vacuo
4. 4
   기타the residue remaining is purified by column chromatography (aluminium oxide basic, activity stage III, ICN; petroleum ether/ethyl acetate=15:1)

실험 절차

A solution of 1 g (3.75 mmol) of trans-O-acetyl-4-(4-chloromethylphenyl)-cyclohexanol in 10 ml of dimethylformamide is mixed with 0.52 g (3.75 mmol) of potassium carbonate and 0.27 g (3.75 mmol) of diethylamine. This mixture is heated to 50° C. for 6 hours with stirring, then water is added and the mixture is extracted with methylene chloride. The organic phase is dried, evaporated down in vacuo and the residue remaining is purified by column chromatography (aluminium oxide basic, activity stage III, ICN; petroleum ether/ethyl acetate=15:1). Colourless oil.

출처