반응 #1751992

반응 방정식

tert-butyl 4-(aminocarbonyl)-4-{[(benzyloxy)carbonyl]amino}piperidine-1-carboxylate

ethanol

→

title compound

4-{[(Benzyloxy)carbonyl]amino}-1-(tert-butoxycarbonyl)piperidine-4-carboxylic acid

반응 조건

후처리

1. 1
   기타The reaction vessel was evacuated
2. 2
   workup.ADDITIONback-filled with nitrogen (3×)
3. 3
   workup.ADDITIONback-filled with hydrogen (1 atm)
4. 4
   여과the mixture was filtered
5. 5
   농축concentrated

실험 절차

Palladium (10% on carbon; 210 mg) was added to a solution of tert-butyl 4-(aminocarbonyl)-4-{[(benzyloxy)carbonyl]amino}piperidine-1-carboxylate (0.43 g, 1.14 mmol) in ethanol (20 mL). The reaction vessel was evacuated and back-filled with nitrogen (3×), then back-filled with hydrogen (1 atm). After 18 h, the mixture was filtered and concentrated to give the title compound (290 mg).

출처