반응 #1747870

반응 방정식

10-[4-(N-phenyl-2-benzimidazolyl)phenyl]phenothiazine

m-chloroperbenzoic acid

KOH

→

10-[4-(N-Phenyl-2-benzimidazolyl)phenyl]phenothiazine 5,5-dioxide

용매

methylene chloride

반응 조건

후처리

1. 1
   온도with cooling
2. 2
   기타After the methylene chloride had been removed
3. 3
   workup.ADDITIONthe suspension was diluted with 100 ml of hot water
4. 4
   여과The precipitate was filtered off with suction
5. 5
   세척washed with hot water
6. 6
   기타dried at 80° C. under reduced pressure
7. 7
   기타The crude product (4.82 g) was recrystallized from 48 ml of acetic acid
8. 8
   기타were obtained

실험 절차

A solution of 6.14 g of 10-[4-(N-phenyl-2-benzimidazolyl)phenyl]phenothiazine in 180 ml of methylene chloride was admixed at room temperature with 7.17 g (28.9 mmol) of 70% m-chloroperbenzoic acid with cooling and stirred at room temperature for 1 h. The solution was admixed with 60 ml of 10% KOH. After the methylene chloride had been removed, the suspension was diluted with 100 ml of hot water. The precipitate was filtered off with suction, washed with hot water and dried at 80° C. under reduced pressure. The crude product (4.82 g) was recrystallized from 48 ml of acetic acid. 3.02 g (46% of theory) of beige microcrystals having an m.p. of 286-288° C. were obtained.

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