반응 #1747855

반응 방정식

3,7-dibromo-10-methylphenothiazine

1-naphthylboronic acid

potassium carbonate

methanol

→

10-methyl-3,7-bis(1-naphthyl)phenothiazine

용매

dimethoxyethane

water

chloroform

반응 조건

후처리

1. 1
   여과filtered
2. 2
   세척The residue was washed with 470 ml of ethanol and hot water
3. 3
   기타dried at 70° C. under reduced pressure
4. 4
   workup.DISSOLUTIONThe solid was dissolved in 100 ml of methylene chloride
5. 5
   여과filtered through silica gel
6. 6
   기타After the solvent had been removed under reduced pressure
7. 7
   기타a tacky mass was obtained which
8. 8
   기타crystallized
9. 9
   workup.STIRRINGwith stirring overnight
10. 10
    여과The crystals were filtered off with suction
11. 11
    세척washed with 300 ml of methanol
12. 12
    기타dried at 40° C. under reduced pressure
13. 13
    기타were obtained
14. 14
    기타The crude product was recrystallized twice from ethyl acetate
15. 15
    기타were obtained

실험 절차

9.30 g (25.1 mmol) of 3,7-dibromo-10-methylphenothiazine, 9.50 g (55.2 mmol) of 1-naphthylboronic acid, 0.407 g (0.50 mmol) of bis(triphenylphosphane)palladium dichloride and 3.80 g (27.5 mmol) of potassium carbonate were heated to boiling under reflux under nitrogen for 5 hours in 204 ml of dimethoxyethane and 101 ml of water. The reaction mixture was cooled to room temperature, stirred further overnight and then filtered. The residue was washed with 470 ml of ethanol and hot water, and dried at 70° C. under reduced pressure. The solid was dissolved in 100 ml of methylene chloride and filtered through silica gel. After the solvent had been removed under reduced pressure, a tacky mass was obtained which, after 200 ml of methanol had been added, crystallized with stirring overnight. The crystals were filtered off with suction, washed with 300 ml of methanol and dried at 40° C. under reduced pressure. 10.33 g of light yellow microcrystals having a melting point of 185-190° C. were obtained. The crude product was recrystallized twice from ethyl acetate. 5.71 g (49% of theory) of analytically pure, almost colorless microcrystals having a melting point of 191-194° C. were obtained, whose solution in chloroform fluoresced at λ=468 nm.

출처