반응 #1741998

반응 방정식

2-amino-3-benzyloxypyridine

ethyl 4-fluorophenylacetimidate hydrochloride

→

product

수율 6.0%

N-(3-(Benzyloxy)-2-pyridyl)-4-fluorophenylacetamidine

수율 6.0%

용매

ethanol

반응 조건

후처리

1. 1
   온도was heated
2. 2
   온도under reflux for 2 hours
3. 3
   기타Evaporation of the solvent
4. 4
   기타gave an oil which
5. 5
   기타purified by flash chromatography (chloroform/methanol)

실험 절차

A mixture of 2-amino-3-benzyloxypyridine (4.84 g, 24.2 mmol) and ethyl 4-fluorophenylacetimidate hydrochloride (5.8 g, 26.7 mmol) in ethanol (80 ml) was heated under reflux for 2 hours. Evaporation of the solvent gave an oil which was converted to the free base and purified by flash chromatography (chloroform/methanol) to obtain the product (0.49 g), m.p. 86°-93° C.

출처