반응 #1741997

반응 방정식

4-fluorophenylacetonitrile

HCl

ethanol

→

Ethyl 4-fluorophenylacetimidate hydrochloride

반응 조건

후처리

1. 1
   기타The solvent was evaporated in vacuo
2. 2
   기타the residual oil triturated with ether
3. 3
   여과The solid was filtered off
4. 4
   세척washed with ether
5. 5
   기타dried (67 g, 83%)
6. 6
   기타used in subsequent steps without further purification

실험 절차

A solution of 4-fluorophenylacetonitrile (50 g, 0.37 mol) in absolute ethanol (300 ml) was treated with dry HCl gas with ice cooling for 1 hour. The solvent was evaporated in vacuo, and the residual oil triturated with ether. The solid was filtered off, washed with ether and dried (67 g, 83%), then used in subsequent steps without further purification.

출처