반응 #1741369

반응 방정식

ethyl(2S)-2-(3,4,5,6-tetrahydro-2H-pyran-2-yloxy)propionate

sodium hydroxide

acetic acid

→

(2S)-2-(3,4,5,6-tetrahydro-2H-pyran-2-yloxy)propionic acid

용매

ethanol

반응 조건

후처리

1. 1
   workup.ADDITIONto which was added, under ice-
2. 2
   온도cooling
3. 3
   온도The reaction mixture was cooled with ice, to which
4. 4
   추출followed by extraction with dichloromethane (200 ml) three times
5. 5
   세척washed with a saturated aqueous saline solution (100 ml) twice
6. 6
   건조by drying over anhydrous magnesium sulfate
7. 7
   workup.DISTILLATIONThe solvent was distilled off under reduced pressure

실험 절차

In ethanol (450 ml) was dissolved ethyl(2S)-2-(3,4,5,6-tetrahydro-2H-pyran-2-yloxy)propionate, to which was added, under ice-cooling, 2N sodium hydroxide solution (150 ml), and the mixture was stirred for one hour at room temperature. The reaction mixture was cooled with ice, to which was added a 27° C. aqueous solution of acetic acid (100 ml), followed by extraction with dichloromethane (200 ml) three times. Dichloromethane layers were combined and washed with a saturated aqueous saline solution (100 ml) twice, followed by drying over anhydrous magnesium sulfate. The solvent was distilled off under reduced pressure to leave (2S)-2-(3,4,5,6-tetrahydro-2H-pyran-2-yloxy)propionic acid (29.5 g) as a colorless waxy product.

출처