반응 #1739030

반응 방정식

sodium sulphate

4-methoxybenzyl 4-hydroxy-4-(3,4-methylenedioxyphenyl)-2-butynoate

→

4-methoxybenzyl 3-[3,4-(methylenedioxy)benzoyl]propiolate

용매

methylene chloride

methylene chloride

반응 조건

후처리

1. 1
   여과filtered over Dicalit
2. 2
   농축concentrated
3. 3
   기타Crystallization of the residue from ether

실험 절차

A solution of 53 g (155 mmol) of 4-methoxybenzyl 4-hydroxy-4-(3,4-methylenedioxyphenyl)-2-butynoate in 400 ml of methylene chloride was added dropwise at 0° to a suspension of 338 g (3.9 mol) of manganese dioxide in 800 ml of methylene chloride The reaction mixture was stirred at 0° for 1 hour, treated with 4 spatula tips of sodium sulphate, suction filtered over Dicalit and concentrated. Crystallization of the residue from ether yielded 4-methoxybenzyl 3-[3,4-(methylenedioxy)benzoyl]propiolate of melting point 113°-114°.

출처