반응 #1736046

반응 방정식

N-Bromosuccinimide

2-phenyl-4-penten-1-ol

water

→

2-(bromomethyl)-4-phenyltetrahydrofuran

수율 70.2%

용매

chloroform

반응 조건

후처리

1. 1
   기타The chloroform layer is separated
2. 2
   건조dried over magnesium sulfate
3. 3
   workup.DISTILLATIONthe solvent is distilled off under reduced pressure
4. 4
   기타The residue is purified by column chromatography on silica gel with chloroform eluant

실험 절차

N-Bromosuccinimide (1.78 g) is added to a stirred solution of 1.6 g of 2-phenyl-4-penten-1-ol in 15 ml of chloroform at room temperature. The resulting mixture is stirred at room temperature for 3 hours. The reaction mixture is then poured into 10 ml of water. The chloroform layer is separated and dried over magnesium sulfate, and the solvent is distilled off under reduced pressure. The residue is purified by column chromatography on silica gel with chloroform eluant to give 1.67 g of 2-(bromomethyl)-4-phenyltetrahydrofuran as colorless oil.

출처