반응 #1735659

반응 방정식

1-benzoyl-3-pyrroline

ethylene glycol

N-bromosuccinimide

water

→

trans-1-benzoyl-3-bromo-4-(2-hydroxyethoxy)-pyrrolidine

반응 조건

후처리

1. 1
   추출followed by extraction with methylene chloride
2. 2
   건조drying over magnesium sulphate and concentration of the solution
3. 3
   기타The residue (188 g) was chromatographed with ethyl acetate on silica gel

실험 절차

95 g (0.55 mol) of 1-benzoyl-3-pyrroline are dissolved in 380 g of ethylene glycol, and 101 g (0.57 mol) of N-bromosuccinimide are added in 5 g portions over a period of 2 hours at room temperature. The mixture is then stirred overnight at room temperature and poured into water, followed by extraction with methylene chloride, drying over magnesium sulphate and concentration of the solution. The residue (188 g) was chromatographed with ethyl acetate on silica gel.

출처