반응 #1729284

반응 방정식

dimethylamine

1,4-dioxa-spiro-[4.5]decane-8-carbaldehyde

potassium cyanide

hydrochloric acid

→

Dimethylamino-(1,4-dioxa-spiro[4.5]dec-8-yl)-acetonitrile

용매

methanol

water

반응 조건

후처리

1. 1
   추출the mixture was extracted with diethyl ether (4×100 ml)
2. 2
   건조The organic phase was dried over sodium sulfate
3. 3
   농축concentrated in vacuo
4. 4
   기타the product was obtained in the form of a white solid

실험 절차

40% aqueous dimethylamine solution (85 ml, 0.67 mol), 1,4-dioxa-spiro-[4.5]decane-8-carbaldehyde (240 g, 0.141 mol) and potassium cyanide (22.05 g, 0.338 mol) were added, while cooling with ice, to a mixture of 4 N hydrochloric acid (37 ml) and methanol (22 ml). The mixture was stirred for 4 d at room temperature; water (80 ml) was added and then the mixture was extracted with diethyl ether (4×100 ml). The organic phase was dried over sodium sulfate and concentrated in vacuo, and the product was obtained in the form of a white solid.

출처