반응 #1726663

반응 방정식

sodium carbonate

9-iodo-10-phenylanthracene

4′-bromobiphenyl-4-boronic acid

→

light yellow powdered solid

수율 40.1%

9-(4′-bromobiphenyl-4-yl)-10-phenylanthracene

수율 40.1%

용매

toluene

toluene

반응 조건

후처리

1. 1
   기타Into a 100 mL three-neck flask were put
2. 2
   기타to be degassed
3. 3
   workup.STIRRINGThe mixture was stirred at 90° C. for 4 hours
4. 4
   여과The mixture was subjected to suction filtration through alumina, Celite (produced by Wako Pure Chemical Industries, Ltd., Catalog No. 531-16855), and Florisil (produced by Wako Pure Chemical Industries, Ltd., Catalog No. 540-00135)
5. 5
   기타The solid obtained by condensation of the obtained filtrate
6. 6
   기타was purified by high-performance liquid chromatography (the mobile phase
7. 7
   기타chloroform) to give a light yellow solid
8. 8
   기타The obtained solid was recrystallized with chloroform/hexane

실험 절차

Into a 100 mL three-neck flask were put 2.8 g (7.2 mmol) of 9-iodo-10-phenylanthracene and 1.5 g (7.2 mmol) of 4′-bromobiphenyl-4-boronic acid, and the atmosphere in the flask was replaced with nitrogen. To the mixture, 40 mL of toluene and 10 mL (2.0 mol/L) of a sodium carbonate aqueous solution were added. The mixture was stirred under reduced pressure to be degassed. After the degassing, 120 mg (0.10 mmol) of tetrakis(triphenylphosphine)palladium(0) was added to the mixture. The mixture was stirred at 90° C. for 4 hours. After the stirring, about 50 mL of toluene was added to the mixture. The mixture was subjected to suction filtration through alumina, Celite (produced by Wako Pure Chemical Industries, Ltd., Catalog No. 531-16855), and Florisil (produced by Wako Pure Chemical Industries, Ltd., Catalog No. 540-00135). The solid obtained by condensation of the obtained filtrate was purified by high-performance liquid chromatography (the mobile phase: chloroform) to give a light yellow solid. The obtained solid was recrystallized with chloroform/hexane to give 1.4 g of a light yellow powdered solid, which was the object of the synthesis, in a yield of 40%.

출처