반응 #172104
ord-62fde1b06d2c4b6c80ab01e03411e537
반응 방정식
시약
없음
반응 조건
상세 조건
See reaction.notes.procedure_details.
후처리
- 1농축It was concentrated in vacuo
- 2기타The residue was purified by HPLC
실험 절차
To a solution of crude 1-(5-cyano-3-fluoro-6-(quinolin-3-ylamino)pyridin-2-ylamino)cyclopentanecarboxamide in EtOH (2 mL) and DMSO (1 mL), aq. 1N NaOH (1 mL) and aq. H2O2 (50%, 1 mL) were added. The mixture was stirred for 1 h. HOAc (0.5 mL) was added. It was concentrated in vacuo. The residue was purified by HPLC to give the titled compound (41 mg). MS 409.4 (M+H); UV 224.1, 243.7, 302.6, 324.8 nm; t 0.495 min.