반응 #172095

반응 방정식

2,6-dichloro-5-fluoronicotinamide

(R)-benzyl-1-(1-aminopropyl)cyclopropylcarbamate hydrochloride salt

DIPEA

→

(R)-benzyl 1-(1-(6-chloro-5-cyano-3-fluoropyridin-2-ylamino)propyl)cyclopropylcarbamate

수율 44.8%

용매

NMP

EtOAc

반응 조건

후처리

1. 1
   세척was washed brine
2. 2
   기타dried
3. 3
   농축concentrated

실험 절차

To a solution of 2,6-dichloro-5-fluoronicotinamide (233 mg, 1.22 mmol) in NMP (5.0 mL) was added (R)-benzyl-1-(1-aminopropyl)cyclopropylcarbamate hydrochloride salt (350 mg, 1.23 mmol) and DIPEA (0.434 mL, 2.44 mmol). After heated at 80° C. for 4 h, the mixture was diluted with EtOAc, organic layer was washed brine, dried and concentrated to give (R)-benzyl 1-(1-(6-chloro-5-cyano-3-fluoropyridin-2-ylamino)propyl)cyclopropylcarbamate (220 mg).

출처