반응 #172017

반응 방정식

Water

2-bromo-4,5-difluorobenzonitrile

tert-butyl (1S,2R)-2-aminocyclohexylcarbamate

DIEA

→

tert-butyl (1S,2R)-2-(5-bromo-4-cyano-2-fluorophenylamino)cyclohexylcarbamate

수율 93.4%

용매

DMSO

반응 조건

후처리

1. 1
   기타precipitation
2. 2
   기타The precipitate was collected
3. 3
   기타dried on vacuum

실험 절차

A solution of 2-bromo-4,5-difluorobenzonitrile (218 mg, 1.00 mmol), tert-butyl (1S,2R)-2-aminocyclohexylcarbamate (214 mg, 1.00 mmol) and DIEA (0.300 mL, 1.72 mmol) in DMSO (2 mL) was stirred at 100 C for 18 h. Water was added to induce precipitation. The precipitate was collected and dried on vacuum to give tert-butyl (1S,2R)-2-(5-bromo-4-cyano-2-fluorophenylamino)cyclohexylcarbamate as a solid (385 mg).

출처