반응 #171982

ord-4ebd6bcad61d4b109b12a7fa6f5023d2

반응 방정식

CC(C)(C)OC(=O)N[C@H]1CCCC[C@H]1Nc1ccc(C(N)=O)c(Nc2cc(-c3ccccc3)no2)c1
tert-butyl (1S,2R)-2-(4-carbamoyl-3-(3-phenylisoxazol-5-ylamino)phenylamino)cyclohexylcarbamate
→
NC(=O)c1ccc(N[C@@H]2CCCC[C@@H]2N)cc1Nc1cc(-c2ccccc2)no1
titled compound
수율 20.9%
NC(=O)c1ccc(N[C@@H]2CCCC[C@@H]2N)cc1Nc1cc(-c2ccccc2)no1
4-((1R,2S)-2-aminocyclohexylamino)-2-(3-phenylisoxazol-5-ylamino)benzamide
수율 20.9%

반응물

CC(C)(C)OC(=O)N[C@H]1CCCC[C@H]1Nc1ccc(C(N)=O)c(Nc2cc(-c3ccccc3)no2)c1
tert-butyl (1S,2R)-2-(4-carbamoyl-3-(3-phenylisoxazol-5-ylamino)phenylamino)cyclohexylcarbamate

시약

없음

용매

O=C(O)C(F)(F)F
TFA

반응 조건

상세 조건
See reaction.notes.procedure_details.

후처리

  1. 1
    기타After 10 min of standing, TFA removed in vacuo
  2. 2
    기타The residue was purified by HPLC

실험 절차

Compound tert-butyl (1S,2R)-2-(4-carbamoyl-3-(3-phenylisoxazol-5-ylamino)phenylamino)cyclohexylcarbamate (6 mg) was dissolved in TFA (1 mL). After 10 min of standing, TFA removed in vacuo. The residue was purified by HPLC to give the titled compound (1 mg). MS 392.4 (M+H); UV 202.9, 294.0 nm

출처

DOI: 10.6084/m9.figshare.5104873.v1특허: US08846928B2uspto-grants-2014_09