반응 #171914
ord-0d9589c7e058451894f1ce443e0d8999
반응 방정식
반응 조건
상세 조건
See reaction.notes.procedure_details.
후처리
- 1세척The reaction mixture was then washed with 2N NaOH, water, brine
- 2건조dried over Na2SO4
- 3기타Solvent was removed in vacuo
실험 절차
EDCI (7.07 g, 36.9 mmol) was added in one portion to a stirred solution of 3-Iodo-5-nitro-benzoic acid (2.31 g, 24.6 mmol), HOBt (4.985 g, 36.9 mmol), 2-Amino-1-methoxypropane (2.73 ml, 24.6 mmol) and NMP (4.06 ml 36.9 mmol) in CH2Cl2 (120 ml) and DMF (10 ml) at 0° C. The reaction was allowed to warm to room temperature and was stirred over night. The reaction mixture was then washed with 2N NaOH, water, brine, and dried over Na2SO4. Solvent was removed in vacuo to give 2.50 g of 3-Iodo-N-(2-methoxy-1-methyl-ethyl)-5-nitro-benzamide as a yellow solid, MS (M+H)=365. This material was used without further purification.