반응 #171448

반응 방정식

1-bromo-4-chloro-2,3-difluorobenzene

2-isopropoxy-4,4,5,5-tetramethyl-1,3,2-dioxa-borolane

→

2-(4-chloro-2,3-difluorophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane

용매

tetrahydrofuran

tetrahydrofuran

반응 조건

후처리

1. 1
   온도to warm up to room temperature
2. 2
   workup.STIRRINGstirred at RT for 1 h

실험 절차

To a solution of 1-bromo-4-chloro-2,3-difluorobenzene (720 mg, 3.17 mmol) in tetrahydrofuran (10 mL) was added i-propylmagesiumchloride (1.90 mL, 3.80 mmol) at 0° C. The reaction mixture was stirred at 0° C. for 1 h. Then 2-isopropoxy-4,4,5,5-tetramethyl-1,3,2-dioxa-borolane (0.98 mL, 4.75 mmol) in tetrahydrofuran (5.0 mL) was added. The reaction mixture was allowed to warm up to room temperature and stirred at RT for 1 h. The mixture was used directly in the next step.

출처