반응 #171170

반응 방정식

compound 0204

4-chloroquinazolin-6-yl acetate

(R)-1-(3-chloro-4-fluoro-phenyl)ethanamine

→

title compound

(R)-4-(1-Phenylethylamino)quinazolin-6-ol

(R)-4-(1-phenylethylamino)quinazolin-6-yl acetate

수율 89.7%

용매

isopropanol

반응 조건

후처리

1. 1
   온도The mixture was cooled to room temperature
2. 2
   기타the resulting precipitate was isolated
3. 3
   세척The solid was washed in turn with isopropanol and methanol
4. 4
   기타dried

실험 절차

A mixture of compound 0204 (1.0 g, 4.5 mmol) and (R)-1-(3-chloro-4-fluoro-phenyl)ethanamine (0.87 g, 5.0 mmol) in isopropanol (45 mL) was stirred at 90° C. for 1 hour. The mixture was cooled to room temperature and the resulting precipitate was isolated. The solid was washed in turn with isopropanol and methanol, dried to provide the title compound (R)-4-(1-phenylethylamino)quinazolin-6-yl acetate as a yellow solid (0.62 g, 61%): LCMS 308 [M+1]+.

출처