반응 #170962

반응 방정식

2-(4-Acetylaminophenoxy)-propionic acid methyl ester

2-(4-Acetylamino-phenoxy)-propionic acid methyl ester

→

9

수율 98.1%

2-(4-Amino-phenoxy)-propionic acid

수율 98.1%

용매

HCl

반응 조건

후처리

1. 1
   workup.DISTILLATIONExcess conc. HCl was distilled off in vacuum
2. 2
   여과filtered hot
3. 3
   여과filtered
4. 4
   기타dried

실험 절차

2-(4-Acetylaminophenoxy)-propionic acid methyl ester 8 (320 g, 1.35 mol) in conc. HCl (8 L) was refluxed for 48 hours. Excess conc. HCl was distilled off in vacuum and filtered hot. The mixture was cooled to 10° C., filtered and dried to give pure 9 (240 g, 81.7%) as a brown powder with an m.p between 175-180° C.

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