반응 #170865

반응 방정식

HCl

NaOH

ethyl 1-(4-chlorobenzyl)-3-methyl-1H-indole-2-carboxylate

water

→

title compound

1-(4-chlorobenzyl)-3-methyl-1H-indole-2-carboxylic acid

용매

EtOH

반응 조건

후처리

1. 1
   workup.ADDITIONwas added
2. 2
   온도the mixture cooled in an ice bath
3. 3
   기타the precipitate collected over a filter

실험 절차

ethyl 1-(4-chlorobenzyl)-3-methyl-1H-indole-2-carboxylate (480 mg, 1.46 mmol) was dissolved in EtOH (15 mL) and 10% aq. NaOH was added (6 mL). The reaction was allowed to stir at rt for 32 h, at which time as much solvent was stripped off as possible, water was added, and the mixture cooled in an ice bath. The mixture was acidified with concentrated HCl and the precipitate collected over a filter. The title compound was obtained as a white powder that was not purified or characterized further. (Yield: 430 mg, 1.435 mmol, 98%)

출처