반응 #170704

반응 방정식

sodium 5-oxo-2,5-dihydrofuran-3-carboxylate

hydrogen

→

titled compound

수율 63.8%

5-Oxotetrahydrofuran-3-carboxylic acid

수율 63.8%

용매

water

반응 조건

후처리

1. 1
   workup.ADDITIONUnder nitrogen atmosphere, an appropriate amount of amberlite IR-120 was added to the reaction solution
2. 2
   여과filtered through Celite
3. 3
   농축The filtrate was concentrated under reduced pressure, ethyl acetate
4. 4
   workup.ADDITIONwas added to the resulting residue
5. 5
   건조the mixture was dried over sodium sulfate
6. 6
   농축again concentrated under reduced pressure

실험 절차

To a solution of sodium 5-oxo-2,5-dihydrofuran-3-carboxylate (150 mg) in water (3 ml) was added 10 wt % palladium on carbon (30 mg), and the mixture was stirred for 18 hours at room temperature under one atm. of hydrogen. Under nitrogen atmosphere, an appropriate amount of amberlite IR-120 was added to the reaction solution, the mixture was stirred at room temperature for 10 minutes, and then filtered through Celite. The filtrate was concentrated under reduced pressure, ethyl acetate was added to the resulting residue, the mixture was dried over sodium sulfate, and then again concentrated under reduced pressure to give the titled compound (83 mg).

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