반응 #170665

반응 방정식

sodium methoxide

water

(cis)-1-(2,4-dimethoxybenzyl)-4-methyl-5-oxopyrrolidine-3-carboxylic acid methyl ester

(trans)-1-(2,4-dimethoxybenzyl)-4-methyl-5-oxopyrrolidine-3-carboxylic acid methyl ester

sodium methoxide

→

titled compound

(Trans)-1-(2,4-dimethoxybenzyl)-4-methyl-5-oxopyrrolidine-3-carboxylic acid

용매

methanol

반응 조건

후처리

1. 1
   온도heated to 55° C.
2. 2
   workup.STIRRINGstirred for 3 hours
3. 3
   workup.STIRRINGthe mixture was stirred at 55° C. for additional 2 hours
4. 4
   온도This reaction solution was cooled to room temperature
5. 5
   workup.STIRRINGthe mixture was stirred overnight
6. 6
   농축The reaction solution was concentrated under reduced pressure
7. 7
   기타to remove methanol
8. 8
   workup.ADDITIONTo the resulting residue was added a 2M aqueous solution of hydrochloric acid (105 ml)
9. 9
   추출the mixture was extracted with ethyl acetate (300 ml)
10. 10
    세척The resulting organic layer was washed with a saturated aqueous solution of sodium chloride
11. 11
    건조dried over anhydrous sodium sulfate
12. 12
    농축concentrated under reduced pressure

실험 절차

To a solution of a mixture of (cis)-1-(2,4-dimethoxybenzyl)-4-methyl-5-oxopyrrolidine-3-carboxylic acid methyl ester and (trans)-1-(2,4-dimethoxybenzyl)-4-methyl-5-oxopyrrolidine-3-carboxylic acid methyl ester (14.2 g) in methanol (150 ml) was added sodium methoxide (about 5M solution in methanol, 28 ml), and the mixture was stirred at room temperature for 16 hours, and then heated to 55° C. and stirred for 3 hours. To this reaction solution was added sodium methoxide (about 5M solution in methanol, 10 ml), and the mixture was stirred at 55° C. for additional 2 hours. This reaction solution was cooled to room temperature, and then water (50 ml) was added thereto, and the mixture was stirred overnight. The reaction solution was concentrated under reduced pressure to remove methanol. To the resulting residue was added a 2M aqueous solution of hydrochloric acid (105 ml), and the mixture was extracted with ethyl acetate (300 ml). The resulting organic layer was washed with a saturated aqueous solution of sodium chloride, and then dried over anhydrous sodium sulfate, and concentrated under reduced pressure to give a crude product of the titled compound (14.0 g).

출처