반응 #1706630

반응 방정식

diethyl ether

iso-butyl 4-((5-methyl-6-(4-(2-oxido-1,3,2-dioxathian-5-yl)phenoxy)pyrimidin-4-yl)oxy)piperidine-1-carboxylate

→

product

Iso-butyl 4-((6-(4-(2,2-dioxido-1,3,2-dioxathian-5-yl)phenoxy)-5-methylpyrimidin-4-yl)oxy)piperidine-1-carboxylate

용매

water

acetonitrile

water

반응 조건

후처리

1. 1
   기타The layers were separated
2. 2
   추출the aqueous layer was extracted with diethyl ether
3. 3
   건조The combined ether layer was dried over sodium sulfate
4. 4
   기타the solvents were evaporated

실험 절차

To a solution of iso-butyl 4-((5-methyl-6-(4-(2-oxido-1,3,2-dioxathian-5-yl)phenoxy)pyrimidin-4-yl)oxy)piperidine-1-carboxylate (100 mg, 0.000198 mole) in acetonitrile (1.2 mL) were added NaIO4 (59 mg, 0.000277 mole) and RuCl3.3H2O (0.5 mg, 0.0000198 mole) in 0.2 mL water. After stirring the suspension at 30° C. for 30 minutes, 0.8 mL water and 1.2 mL diethyl ether were added. The layers were separated, and the aqueous layer was extracted with diethyl ether. The combined ether layer was dried over sodium sulfate, the solvents were evaporated to yield 50 mg product as white solid.

출처