반응 #170283

반응 방정식

HCl

1-methoxy-3-(oxiran-2-ylmethoxy)-9H-xanthen-9-one

→

title compound

수율 71.3%

3-(3-chloro-2-hydroxypropoxy)-1-methoxy-9H-xanthen-9-one

수율 71.3%

용매

ethyl acetate

반응 조건

후처리

1. 1
   기타the reaction solvent was removed under reduced pressure
2. 2
   workup.ADDITIONEther was added to the residue
3. 3
   기타followed by sonication
4. 4
   기타the solvent was removed

실험 절차

Aqueous ethyl acetate 1M-HCl (3 mL) was added to 1-methoxy-3-(oxiran-2-ylmethoxy)-9H-xanthen-9-one (25 mg, 0.08 mmol) prepared in Step 4 of Example 9, followed by stirring at room temperature for 30 minutes, and the reaction solvent was removed under reduced pressure. Ether was added to the residue, followed by sonication, and the solvent was removed to give the title compound (20 mg, 71.3%) as a reddish brown solid.

출처