반응 #1702094

반응 방정식

(2-Benzyloxycarbonylamino-ethyl)-methyl-phosphinic acid ethyl ester

EtOH

→

(2-amino-ethyl)-methyl-phosphinic acid ethyl ester

수율 90.0%

용매

EtOAc

반응 조건

후처리

1. 1
   기타was run at room temperature
2. 2
   여과The reaction was then filtered through Supercell NF
3. 3
   농축the filtrate was concentrated

실험 절차

(2-Benzyloxycarbonylamino-ethyl)-methyl-phosphinic acid ethyl ester (1.3 g, 4.56 mmol) and 10% Pd/C (485 mg) were combined in a flask and EtOH (46 mL) was added. The reaction flask atmosphere was exchanged for H2 and the reaction was run at room temperature until complete, as determined by TLC (eluent: 100% EtOAc). The reaction was then filtered through Supercell NF and the filtrate was concentrated to yield (2-amino-ethyl)-methyl-phosphinic acid ethyl ester (615 mg, 90%) as a yellow oil in which white crystals began to form under high vacuum.

출처