반응 #1702077

반응 방정식

diethylether

2-(4-chlorophenyl)ethanol

Dess-Martin periodinane

→

desired compound

수율 42.2%

2-(4-chlorophenyl)acetaldehyde

수율 42.2%

용매

dichloromethane

반응 조건

후처리

1. 1
   세척the resulting mixture was washed with a 1:1 solution (150 ml) of sodium carbonate (aqueous saturated) and sodium thiosulfate (aqueous saturated)
2. 2
   건조The organic phase was then dried over sodium sulfate
3. 3
   기타evaporated

실험 절차

To a solution of 2-(4-chlorophenyl)ethanol (2.00 g, 12.77 mmol) in dichloromethane (100 ml) was added Dess-Martin periodinane (8.12 g, 19.16 mmol) and the mixture was stirred at room temperature over weekend. Then was added diethylether (150 ml) and the resulting mixture was washed with a 1:1 solution (150 ml) of sodium carbonate (aqueous saturated) and sodium thiosulfate (aqueous saturated) and then with sodium bicarbonate (aqueous saturated) and finally with brine. The organic phase was then dried over sodium sulfate and evaporated. Silica gel flash chromatography (pentan/ethylacetate:9/1) afforded the desired compound (0.834 g, 42%) as a white solid.

출처